en بیماری های دهان Oral & Maxillofacial Medicine پژوهشي Research <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><span calibri=""><strong><span tahoma="">Background</span></strong><span lang="EN-GB" tahoma=""><strong>:</strong> Candida albicans is the most prevalent cause of oral fungal infections. This study aimed to compare the effectiveness of different dilutions of Aloe vera extracts (water and alcoholic )in inhibiting the growth of oral Candida albicans compared to nystatin.</span><span style="font-family:"Tahoma",sans-serif"></span></span><br> <span calibri=""><span lang="EN-GB" tahoma=""><strong>Materials and Methods:</strong> </span>&nbsp;<span lang="EN-GB" tahoma="">This study was an experimental and laboratory investigation of a common strain of Candida albicans species in Iran. Different dilutions (1.56, 3.12, 6.25, 12.5, 25, 50, 100, and 200 mg/ml) of alcoholic and water extracts of Aloe vera and nystatin were prepared. </span><span tahoma="">The study measured the diameter of the inhibition zone of Candida albicans and assessed the impact of nystatin or Aloe vera extracts on this parameter. All data were analyzed using two-way ANOVA, </span><span tahoma="">Post hoc Bonferroni test</span><span tahoma="">,</span><span lang="EN-GB" tahoma=""> and t-test (&alpha;= 0.05).</span></span><br> <span calibri=""><span lang="EN-GB" tahoma=""><strong>Results:</strong> Both water and alcoholic extracts of Aloe vera at a concentration of 200 mg/ml produced a larger non-growth halo. Water extracts were more effective than alcoholic extracts at certain dilutions (p<0.001). Both water and alcoholic Aloe vera extract dilutions showed better results than nystatin (p<0.001).</span><br> <span lang="EN-GB" tahoma=""><strong>Conclusion:</strong> The antifungal efficacy of water-soluble Aloe vera was significantly superior to alcoholic extracts and nystatin.</span></span></span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span calibri="" style="font-family:"><span style="font-family:"Tahoma",sans-serif"></span></span></span></span></div> &nbsp; Aloe vera, Nystatin, Candida albicans 32 36 http://cofs.khuisf.ac.ir/browse.php?a_code=A-10-1-43&slc_lang=en&sid=1 Forough Ahmadi 1003194753284600861 1003194753284600861 No Faculty of dentistry, Isfahan (khorasgan) Branch, Islamic Azad University, Isfahan, Iran Amir Mansour Shirani 1003194753284600862 1003194753284600862 Yes Department of Oral diseases, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran Bahareh Bagheri Todashki 1003194753284600863 1003194753284600863 No Department of Oral diseases, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran