fa آسیب شناسی دهان و دندان Oral & Maxillofacial Pathology پژوهشي Research <span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:&quot;Aptos&quot;,sans-serif"><b><span style="font-family:&quot;Times New Roman&quot;,serif">Background</span></b><span style="font-family:&quot;Times New Roman&quot;,serif">: The purpose of this study was to gather current information on the epidemiology and treatment of actinomycotic periapical lesions by summarizing prior research on clinical and management strategies for prevention and treatment. </span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:&quot;Aptos&quot;,sans-serif"><b><span style="font-family:&quot;Times New Roman&quot;,serif">Methods</span></b><span style="font-family:&quot;Times New Roman&quot;,serif">: In this review, recent case reports available in full were selected from the PubMed and Google Scholar databases, focusing on publications between 2015 and 2025 that specifically addressed Periapical Actinomycosis.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:&quot;Aptos&quot;,sans-serif"><b><span style="font-family:&quot;Times New Roman&quot;,serif">Conclusion</span></b><span style="font-family:&quot;Times New Roman&quot;,serif">: This study indicates that practitioners should remain vigilant for peri-radicular actinomycotic infections, particularly in instances of recurrent sinus tracts and inadequate responses to conventional treatments. Confirmation of this diagnosis should be achieved through biopsy and microscopic evaluation. The proposed management strategies for periapical lesions associated with actinomycotic infection varied among patients, depending on the extent of the lesion and the risk of developing a cervicofacial infection, including endodontic retreatment, periapical surgery, and/or antibiotics, or 0.2% chlorhexidine mouthwash, with prolonged follow-up.</span></span></span></span><br> &nbsp; 0 0 http://cofs.khuisf.ac.ir/browse.php?a_code=A-10-1-81&slc_lang=fa&sid=1 Mehdi Abrishami 10031947532846001338 10031947532846001338 No Department of oral and maxillofacial Surgery, Faculty of Dentistry, Isf.C., Islamic Azad University, Isfahan, Iran Atousa Aminzadeh Gohari 10031947532846001339 10031947532846001339 No Department of Oral & maxillofacial Pathology, Faculty of Dentistry, Isf.C., Islamic Azad University, Isfahan, Iran Laleh Hoveida 10031947532846001340 10031947532846001340 No Department of Microbiology, Isf.c., Islamic Azad university, Isfahan, Iran Bardia Hasani 10031947532846001341 10031947532846001341 Yes Department of Endodontics, Faculty of Dentistry, Isf.C., Islamic Azad university, Isfahan, Iran Hila Abdollahzadeh 10031947532846001342 10031947532846001342 No Faculty of dentistry, Isf.C., Islamic Azad University, Isfahan, Iran