[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
publication ethics::
Abstracting and Indexing::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..

Citation Indices from GS

AllSince 2020
Citations88
h-index11
i10-index00
..
:: Volume 3, Issue 2 (5-2025) ::
cofs 2025, 3(2): 22-27 Back to browse issues page
Comparison of Seven Days Use of Chlorhexidine Before and After Third Molar Surgery in Preventing Dry Socket
Nima Aghaei , Mehdi Abrishami * , Somayeh Abbasi , Behrooz Moradbeig
Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Isf.C, Islamic Azad University, Isfahan, Iran
Abstract:   (231 Views)
Background: Dry socket is a common complication following third molar extraction, characterized by sudden and severe pain that typically begins several days post-procedure, with an incidence rate of approximately 35%. This study aimed to investigate the effect of 0.12% chlorhexidine on the incidence of dry socket and the associated pain in patients undergoing surgery for maxillary and mandibular third molars.
Materials and Methods: In this clinical trial, 105 patients with non-impacted or partially impacted wisdom teeth were selected and divided into three groups. The first group used chlorhexidine mouthwash for seven days prior to surgery, while the second group used it for seven days afterward at 12-hour intervals. The third group (control) used gauze soaked in standard normal saline (0.9% sodium chloride) at the wound site. Cases of dry socket occurrence were recorded. Data were analyzed using chi-square, Fisher's, and Kruskal-Wallis tests.
Results: The incidence of dry socket was 3.4% in the first group, 5.1% in the second group, and 5.4% in the control group, with no statistically significant difference between the groups (p>0.05). Additionally, gender, oral hygiene level, smoking, type of surgery, and surgical site had no significant impact on the occurrence of this complication (p>0.05).
Conclusion: The use of chlorhexidine does not have a significant effect on preventing the occurrence of dry socket. However, there are no contraindications for its use.
 
Full-Text [PDF 245 kb]   (57 Downloads)    
Type of Study: Research | Subject: Oral Medicine
Received: 2024/08/18 | Accepted: 2025/01/19 | Published: 2025/05/20
References
1. Blum IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg. 2002;31(3):309-317 [DOI:10.1054/ijom.2002.0263] [PMID]
2. Nusair YM, Younis MH. Prevalence, clinical picture, and risk factors of dry socket in a Jordanian dental teaching center. J Contemp Dent Pract. 2007;8(3):53-63. [DOI:10.5005/jcdp-8-3-53]
3. Parthasarathi K, Smith A, Chandu A. Factors affecting incidence of dry socket: a prospective community-based study. J Oral Maxillofac Surg. 2011;69(7):1880-1884. [DOI:10.1016/j.joms.2010.11.006] [PMID]
4. Hermesch CB, Hilton TJ, Biesbrock AR, Baker RA, Cain-Hamlin J, McClanahan SF, et al. Perioperative use of 0.12% chlorhexidine gluconate for the prevention of alveolar osteitis: efficacy and risk factor analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(4):381-387. [DOI:10.1016/S1079-2104(98)90061-0] [PMID]
5. Ren YF, Malmstrom HS. Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials. J Oral Maxillofac Surg. 2007;65(10):1909-1921. [DOI:10.1016/j.joms.2007.03.004] [PMID]
6. Bystedt H, Nord CE, Nordenram A. Effect of azidocillin, erythromycin, clindamycin and doxycycline on postoperative complications after surgical removal of impacted mandibular third molars. Int J Oral Surg. 1980;9(3):157-165. [DOI:10.1016/S0300-9785(80)80014-7] [PMID]
7. Nitzan DW. On the genesis of "dry socket". J Oral Maxillofac Surg. 1983;41(11):706-710. [DOI:10.1016/0278-2391(83)90185-4] [PMID]
8. Krekmanov L, Nordenram A. Postoperative complications after surgical removal of mandibular third molars. Effects of penicillin V and chlorhexidine. Int J Oral Maxillofac Surg. 1986;15(1):25-29. [DOI:10.1016/S0300-9785(86)80007-2] [PMID]
9. Ragno JR Jr, Szkutnik AJ. Evaluation of 0.12% chlorhexidine rinse on the prevention of alveolar osteitis. Oral Surg Oral Med Oral Pathol. 1991;72(5):524-526. [DOI:10.1016/0030-4220(91)90487-W] [PMID]
10. Larsen PE. The effect of a chlorhexidine rinse on the incidence of alveolar osteitis following the surgical removal of impacted mandibular third molars. J Oral Maxillofac Surg. 1991;49(9):932-937. [DOI:10.1016/0278-2391(91)90055-Q] [PMID]
11. Happ JR, Ellis E, Tucker MR. Contemporary Oral and Maxillofacial Surgery. 7th ed. St Louis: Elsevier, 2019; 214 -220.
12. Vezeau PJ. Dental Extraction Wound Management: Medicating Postextraction Sockets. J Oral Maxillofacial Surg. 2000;58 (5): 531 - 537. [DOI:10.1016/S0278-2391(00)90016-8] [PMID]
13. Houston JP, McCollum J, Pietz D, Schneck D. Alveolar osteitis: a review of its etiology, prevention, and treatment modalities. Gen Dent. 2002;50(5):457-465.
14. Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA. Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2006;11(2):E179-E184.
15. Torres-Lagares D, Gutierrez-Perez JL, Infante-Cossio P, Garcia-Calderon M, Romero-Ruiz MM, Serrera-Figallo MA. Randomized, double-blind study on effectiveness of intra-alveolar chlorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. Int J Oral Maxillofac Surg. 2006;35(4):348-351. [DOI:10.1016/j.ijom.2005.08.002] [PMID]
16. Delilbasi C, Saracoglu U, Keskin A. Effects of 0.2% chlorhexidine gluconate and amoxicillin plus clavulanic acid on the prevention of alveolar osteitis following mandibular third molar extractions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(3):301-304. [DOI:10.1067/moe.2002.125200] [PMID]
17. Iordanskii A, Zhulkina A, Olkhov A, Fomin S, Burkov A, Stilman M. Characterization and Evaluation of Controlled Antimicrobial Release from Petrochemical (PU) and Biodegradable (PHB) Packaging. Polymers (Basel). 2018;10(8):817. [DOI:10.3390/polym10080817] [PMID] []
18. Brägger U, Schild U, Lang NP. Effect of chlorhexidine (0.12%) rinses on periodontal tissue healing after tooth extraction. (II). Radiographic parameters. J Clin Periodontol. 1994;21(6):422-430. [DOI:10.1111/j.1600-051X.1994.tb00740.x] [PMID]
19. Haraji A, Khamverdi N, Khanzadealishahi H. The Effect of 0.2 % Chlorhexidine Gel in Prevention of Pain and Dry Socket Following Mandibular Third Molar Surgery. J Res Dent Sci 2012; 9(2):63-67
20. Minguez-Serra MP, Salort-Llorca C, Silvestre-Donat FJ. Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens. Med Oral Patol Oral Cir Bucal. 2009;14(9):e445-e449.
21. De Siena F, Francetti L, Corbella S, Taschieri S, Del Fabbro M. Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the treatment of peri-implant mucositis. An observational study. Int J Dent Hyg. 2013;11(1):41-47. [DOI:10.1111/idh.12002] [PMID]
22. Salami AA, Imosemi IO, Owoeye OO. A comparison of the effect of chlorhexidine, tap water and normal saline on healing wounds. Int J Morphol 2006; 24(4):673-676. [DOI:10.4067/S0717-95022006000500025]
23. Saatman RA, Carlton WW, Hubben K, Streett CS, Tuckosh JR, DeBaecke PJ. A wound healing study of chlorhexidine digluconate in guinea pigs. Fundam Appl Toxicol. 1986;6(1):1-6. [DOI:10.1016/0272-0590(86)90258-7] [PMID]
24. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 5th ed. St.louis: Elsevier, 2023.
25. Bonine FL. Effect of chlorhexidine rinse on the incidence of dry socket in impacted mandibular third molar extraction sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(2):154-158. [DOI:10.1016/S1079-2104(05)80273-2] [PMID]
26. Newman MG, Takei HH, Klokkevold PR, Carranza FA. Newman and Carranza's clinical periodontology. 13th ed. Philadelphia: Elsevier. 2019. P: 599 -600.
27. Kaczor-Urbanowicz K, Zadurska M, Czochrowska E. Impacted Teeth: An Interdisciplinary Perspective. Adv Clin Exp Med. 2016;25(3):575-585. [DOI:10.17219/acem/37451] [PMID]
28. Ayrancı F, Omezli MM, Sivrikaya EC, Rastgeldi Z. Prevalence of Third Molar Impacted Teeth: A Cross -Sectional Study Evaluating Radiographs of Adolescents. Journal of Clinical and Experimental Investigations 2017; 8(2): 50 -53. [DOI:10.5799/jcei.333381]
29. Mallya SM, Lam EWN. White and Pharoah's oral radiology: principles and interpretation. 8th ed. St.Louis: Elsevier Health Sciences; 2019: 467.
30. Birn H. Etiology and pathogenesis of fibrinolytic alveolitis (dry socket). Int J Oral Surg 1973;2(5):215-63 [DOI:10.1016/S0300-9785(73)80045-6]
31. Eshghpour M, Rezaei NM, Nejat A. Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: a single-blind randomized clinical trial. J Oral Maxillofac Surg. 2013;71(9):1484-1489. [DOI:10.1016/j.joms.2013.05.004] [PMID]
32. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 2008;66(3):441-445. [DOI:10.1016/j.joms.2007.06.641] [PMID]
33. Berwick JE, Lessin ME. Effects of a chlorhexidine gluconate oral rinse on the incidence of alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg. 1990;48(5):444-449. [DOI:10.1016/0278-2391(90)90227-S] [PMID]
34. Larsen PE. Use of chlorhexidine to prevent alveolar osteitis. J Oral Maxillofac Surg. 1990;48(11):1244-1245. [DOI:10.1016/0278-2391(90)90570-R] [PMID]
35. Babar A, Ibrahim MW, Baig NJ, Shah I, Amin E. Efficacy of intra-alveolar chlorhexidine gel in reducing frequency of alveolar osteitis in mandibular third molar surgery. J Coll Physicians Surg Pak. 2012;22(2):91-94.
36. Caso A, Hung LK, Beirne OR. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(2):155-159. [DOI:10.1016/j.tripleo.2004.05.009] [PMID]
37. Hamid S, Memon M, Ali R, Shams S. Use of chlorhexidine 0.2% gel to prevent alveolar osteitis in mandibular third molar surgical extraction. Professional Med J 2020; 27(8):1606-1611. [DOI:10.29309/TPMJ/2020.27.08.4264]
38. Celikoglu M, Miloglu O, Kazanci F. Frequency of agenesis, impaction, angulation, and related pathologic changes of third molar teeth in orthodontic patients. J Oral Maxillofac Surg. 2010;68(5):990-995. [DOI:10.1016/j.joms.2009.07.063] [PMID]
Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Aghaei N, Abrishami M, Abbasi S, Moradbeig B. Comparison of Seven Days Use of Chlorhexidine Before and After Third Molar Surgery in Preventing Dry Socket. cofs 2025; 3 (2) :22-27
URL: http://cofs.khuisf.ac.ir/article-1-87-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 2 (5-2025) Back to browse issues page
Contemporary Orofacial Science Contemporary Orofacial Science
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4714